Yesterday I was trying to link Timeslips 2015 and Sage 50 2015 for a new client.  I had both programs open and when trying to set the path to the Sage 50 company I get got an error (that came from Sage 50) saying:
 "Sage 50 is already running.  To open another company, select File > Open Company from within Sage 50."    

It was like it was trying to open Sage 50, even though it was already open.  When I clicked OK, I saw the Timeslips error message:
Timeslips Accounting Link has encountered an error.  Sage Timeslips could not communicate with Sage 50.  Make sure that Sage 50 is running.  If Sage 50 is currently displaying a message, close the message and try your action again."  

I suspect there's some weird permissions type issue and I have scheduled to work on it with the IT guy tomorrow, but figured I'd throw it out to the group to see if anyone has run into a similar issue with TAL Pro.